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Corona Family of Universal Charged Aerosol Detectors

The award-winning Corona CAD (charged aerosol detector) has been widely adopted by every leading pharmaceutical company worldwide because it solves analytical challenges that no other technology can! Robust and easy to use for operators with minimal training, the Corona is ideally suited for both the methods-development lab and the factory floor.


A top scientist at a leading pharmaceutical company
put it this way:

Corona® ultra™ for UltiMate 3000 Systems

Corona CAD White Papers“I do not know of any other bench-top device that can reliably quantitate proteins, peptides, and small molecules in the same analytical run. The Corona CAD has the potential to become the benchmark chromatographic detector throughout the pharmaceutical industry.”

Simple, intuitive operation

A robust, reliable, plug-and-play device, Corona requires no calibration or optimization – so even those with minimal training can run it. Operators need only inject the sample, turn on the nitrogen gas, and press one button to get results – we’ve put all the sophistication and complexity inside the box.


Whether you are trying to detect proteins, lipids, carbohydrates, or small molecules; whether you are doing excipient and formulation characterization, forced-degradation studies, impurity analysis, cleaning validations, or final product QC – the Corona CAD lets you see what you’ve been missing. Click on the benefits below to learn more:

Click here to see the new Corona® ultra™   Click here to see the Corona® CAD®

The technology behind the tool

CAD is based on established evaporative techniques that have been deployed effectively in evaporative light scattering detectors (ELSD) and liquid chromatography-mass spectrometry (LC-MS) systems. However, the back end – the charged aerosol detector – is a completely new detection methodology for HPLC. We discovered that by marrying the new aerosol techniques with established evaporative technology, we would be able to meet market needs never before addressable with traditional detection technologies. Thermo Scientific Dionex integrated the two technologies to design an entirely new class of instrument. The combination offers orders-of-magnitude advantages in sensitivity, dynamic range, consistency, and reproducibility, making the Corona CAD the first truly universal HPLC detector. Click here to see inside the Corona CAD. Click here to read about limitations of traditional technologies in pharmaceutical applications, or here to see at a glance how Corona CAD compares to traditional technologies.



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