Electrochemical synthesis cells

ESA’s new, high-efficiency, high-capacity electrochemical cells make it easy to synthesize significant quantities of difficult-to-obtain metabolites from a variety of parent compounds. Since the user can control the systems’ oxidation capability to generate specific, desired oxidation products, they have wide utility in a variety of metabolite-generation tasks.

We designed two synthesis cells to suit specific application needs. The 5150 cell has high capacity and is preferred for low-potential (<500 mV) oxidation reactions, while the 5125 cell is recommended for high-potential reactions. Although smaller in volume, the 5125 cell minimizes unwanted over-oxidation reactions.  These cell’s solid-state design is virtually maintenance free, no special filling solutions or polishing are required.

Features and benefits

• Biologically relevant – cells mimic much of the oxidation capabilities of cytochrome P450, a key enzyme family that is responsible for metabolizing most drugs.
• High product yield – cells can generate microgram quantities of product with a single injection of starting compound.
• In-line synthesis capability – cells are integrated into either analytical or semi-preparative HPLC system for easy purification of reaction products.

Low volume cell for EC-MS

The Model 5030 Cell is a low volume electrochemical cell optimized for the low flow rates of electrospray ionization mass spectrometry (ESI-MS). This cell is optimized to minimize band spreading at flow rates of 250 µL / min or less. This makes the cell ideal for incorporation into MS, MS-MS and LC-MS systems.

Proven Coulometric Design

The Model 5030 Cell utilizes the proven porous graphite flow through design pioneered by ESA and is optimized for incorporation into an LC-MS system as a reactor cell to enhance ionization of analytes or to provide data relevant to processes in drug development.

When combined with an MS system the 5030 cell has been shown to enhance the sensitivity and applicability of Mass Spectrometers by providing enhanced ionization and increased signal from difficult to ionize molecules for MS analysis, including:

Diagram of typical EC-MS System