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Drug DiscovArray® system – a multi-functional system for pharmaceutical discovery applications

Assessing a compound's inherent chemical properties and pharmacological characteristics using various in vitro and in vivo assays is a crucial step in determining a compound's suitability for drug development. Accurately predicting the fate of a compound once it is administered as a therapeutic remains a significant challenge in any drug-discovery operation.

Using chemistry to better understand biology

For many years, EC systems merely measured the flow of electrons (e-) generated from redox reactions to measure a given analyte. But in the past few years, researchers have begun to understand and exploit the ability of EC systems to perform oxidation/ reduction reactions to mimic and study many important biological processes. It is well known that many key biological and pharmacological properties of compounds have their basis in redox chemistry.

Our customers were looking for an optimal platform to study the important chemical and pharmacological properties of potential drug candidates, and ESA has delivered with the DiscovArray® – a powerful combination of electrochemical cell and array that can perform all redox applications in a single system. The DiscovArray system represents a major leap forward in drug discovery and development operations:

Formats in a single platform for maximum efficiency
Ability to perform all EC applications, including traditional EC detection
Easy integration into LC or LC-MS systems
Simple operation, instrument control, and data-management tools
Easy integration with most bioanalytical and data-analysis systems
Quick switching between applications with minimal time and effort
Easily customized to fit your application needs.

System components
	70-4334	Model 5600A CoulArray Detector, 16 Channel
	70-4340T	CoulArray Organizer with Temperature Control
	70-4051	Gradient Upgrade for CoulArray System
	70-4772	Monitor, Option, LCD Color Flat Panel (TFT), 19” viewing area
	70-1838	Cable, Dual Channel for Coulochem III with DC Control (Connect one or two single-channel cells 5020/5021(A)/5040/5041 to CoulArray series detector)
	70-5971	High Voltage Ground Decoupler Kit for Coulochem III (for use with ESA EC reactor cells and/or MS systems to isolate high voltage from ground)
	70-7058	Model 584 Pump with RS-232 Serial Control for use in ESA HPLC Systems
	70-7057	Gradient Upgrade for ESA HPLC Systems (CoronaCAD, Models 526, 528, 530 with Elite CDS & CoulArray detectors)
	70-4151	Model 542 Autosampler with Sample Tray Cooling, Biocompatible Fluid Path and Standard vial tray (84 position)
	70-4740	Validation, CoulArray Electrochemical Array System
	70-1838	Cable, Single Channel Cell to CoulArray Series Detector