Neurochemistry Analyses

There have been many advances in neurochemistry over the years, and ESA Biosciences technology has played a key role in many of them. Now, you can benefit from our resident neurochemistry experts’ years of experience and let ESA Laboratories do your critical neurochemistry analyses for you. We have developed methods optimized for the best sensitivity, selectivity, and robustness using all the available cells and detectors, along with written procedures, so you can count on the results. Ask us about the following neurochemistry services:

Amino Acids The study of low level amino acids in microdialysis perfusates is accomplished using pre-column derivitization with o-phthaldialdehyde (OPA)/2-mercaptoethanol (BME) prior to detection with ESA's Coulochem^® III electrochemical detector.

Catecholamines Various medical conditions have been associated with increased levels of norepinephrine, epinephrine, and dopamine. We use ESA’s CoulArray^® detector-based system to accurately measure catecholamines in plasma or urine samples.

Monoamines Various columns, cells, and mobile phases are available for contract studies to measure a variety of monoamines and metabolites from tissue samples, microdialysis perfusates, and cell culture samples.

Acetycholine, a monoamine, is the primary neurotransmitter of cholinergic neurons. ESA’s sensitive detector technology allows for a detection limit of 50 fmol for acetylcholine in microdialysis samples collected with 50 nM Neostigmine.

Free D-Serine and D-Aspartic Acid in brain tissue.  These two amino acids can now be quantitated using a derivitization technique and HPLC-fluorescence.