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Metabolite Quantitation in the Age of MIST

Event Overview: The importance of metabolites in assessing drug safety is becoming a more critical element of the drug development process. One challenge is assessing the relative amounts of metabolites when standards are unavailable, especially when relative response can vary over several orders of magnitude. This, as well as other challenges, requires new analytical approaches. Presented is an assessment of UHPLC and charged aerosol detection coupled with UV and MS for semi-quantitative estimation of metabolites. The use of an inverse compensate gradient to ensure semi-quantitative response, in combination with universal detection strategies is also explored.

Event Date:  Wednesday, September 22, 2010 at 11:00 am EDT, 15:00 GMT

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